所受教育

1. 学士 （1987年9月-1991年7月） 必赢线路检测3003

2. 硕士 （1991年9月-1994年7月） 必赢线路检测3003  导师：沈富仁 教授

3. 博士 （2000年3月-2003年2月） 浙江大学  导师：黄宪 院士

职称职位

1. 1994年-现在 必赢线路检测3003 研究实习员 助理研究员 副研究员 教授

2. 2005年3月-2006年3月 香港中文大学 博士后研究员

3. 2004年7月-现在 硕士生导师

4. 2005年 安徽省高校中青年优秀骨干教师

5. 2010年 安徽省学术和技术带头人后备人选

6. 2010年4月-现在 博士生导师

主持项目

1. “贫电子炔烃的加成反应及其在有机合成中的应用研究”，国家自然科学基金，       2013年1月-2016年12月，项目负责人(****2004)

2. “有机金属试剂在共轭烯炔类化合物的立体选择性合成中的应用”，国家自然科学基金， 2008年1月-2010年12月，项目负责人(****2001)

3. “炔基砜的碳金属化反应及其在多取代烯烃合成中的应用”,国家自然科学基金，2007年1月-2009年12月，项目负责人 (****2001)

4. 有机金属试剂与官能化炔烃的加成反应及其在多取代烯烃合成中的应用       安徽省教委基金，2005年1月-2006年12月，项目负责人(2005KJ129)

5. 官能化的烯基金属试剂的制备及其在多取代烯烃的立体选择性合成中的应用       安徽省教委基金，2003年1月-2004年12月，项目负责人

研究领域

1. 金属有机化学

2. 有机合成

讲授课程

1. 有机化学

2. 高等有机化学

3. 基础化学实验

4. 综合化学实验

获奖情况

1. 王绍武，叶钟文，沈富仁， 谢美华 等，“镧系金属配合物的研究-合成、性质与结构”， 1998 年 安徽省高等学校科技进步一等奖

2. 王绍武，马怀柱，叶钟文，沈富仁， 谢美华 “稀土金属配合物的研究-合成、性质与结构”， 2000 年 安徽省自然科学二等奖

发表论文

1.  Guo Ziyi, Zhang Junjie, Zhang Jitan*, Xie Meihua* Electrochemical Rhodium-catalyzed C-H Cyclodimerization of Alkynes to Access Diverse Functionalized Naphthalenes Org. Lett. 2022, 24 , 7784-7789. https://doi.org/10.1021/acs.orglett.2c03122.
   

2.  Zhang Ji-Tan†,*, Fan Jian†, Guo Ziyi, Wu Yehe, Wu Jiaping*, Xie Mei-Hua* Pd-Catalyzed Atroposelective Interannular C-H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy Adv. Synth. Catal. 2022, 364, 3589-3599. doi.org/10.1002/adsc.202200659.

3.  Guo Zi-Yi, Li Ke-Ru, Li Hang, Wang Xu, Zhang Ji-Tan,* Xie Mei-Hua* Synchronous Synthesis of Benzo[d]oxazoles/Benzo[d]thiazoles and 1-Arylethan-1-ones Enabled by Acid-promoted C-C Triple Bond Cleavage of Ynones Eur. J. Org. Chem., 2022, 2022, e202200858 (1 of 4), doi.org/10.1002/ejoc.202200858.

4.  Zhang Ji-Tan,*, Fan Jian^†, Wu Yehe^†, Guo Ziyi, Wu Jiaping*, Xie Mei-Hua* Pd-Catalyzed Atroposelective C-H Acyloxylation Enabling Access to an Axially Chiral Biaryl Phenol Organocatalyst Org. Lett. 2022, 23, 5143-5148. DOI: 10.1021/acs.orglett.2c01981.

5.  Zhao Yi-Ming^†, Wang Xu^†, Guo Zi-Yi, Li Hang, Zhang Ji-Tan,* Xie Mei-Hua* Cu-catalyzed Diarylthiolation of Ynones with Aryl Iodides and Elemental Sulfur: An Access to Tetrasubstituted (Z)-1,2-Bis(arylthio)alkenes and Benzo[b][1,4]dithiines J. Org. Chem., 2022, 87, 11796-11804. doi.org/10.1021/acs.joc.2c01575.

6.  Liu Chang-Qing, Li Hang, Wang Bo, Guo Zi-Yi, Wang Yu, Zhang Ji-Tan*, Xie Mei-Hua* Temperature Controlled Di- and Monosulfonylation of Propargyl Alcohols with Sodium Sulfinates: Switchable Access to (E)-Allyl, Vinyldisulfones and Propargyl Sulfones Org. Chem. Front., 2022, 9, 1855-1860. DOI: 10.1039/d1qo01906f.

7.  Zhang Jitan,* Wu Manyi, Ju Hu, Yang Haitao, Qian Baiyang, Ding Ke, Wu Jiaping* and Xie Meihua* “K₂S₂O₈-mediated acylarylation of unactivated alkenes via acyl radical addition/C–H annulation cascade of N-allyl-indoles with silver cocatalysis” Org. Chem. Front., 2022, 9, 32-38. 10.1039/d1qo01069g

8.  Zhang Jitan*, Xu Qiaoqiao, Fan Jian, Zhou Lan, Liu Nannan, Zhu Li, Wu Jiaping*, Xie Meihua* “Pd(II)-Catalyzed enantioconvergent twofold C–H annulation to access atropisomeric aldehydes: a platform for diversity-oriented-synthesis” Org. Chem. Front. 2021, 8, 3404-3412. DOI: 10.1039/d1qo00183c

9. Guo Ziyi, Zhao Yiming; Wang, Yu, Xie Meihua*, Zhang Jitan* “Construction of 3-Sulfonyl Naphthalenes via Tandem Reaction of 1,4-Diyn-3-yl Esters with Sodium Sulfinates” J. Org. Chem., 2021, 86 , 6247-6258. doi.org/10.1021/acs.joc.1c00038

10. Fan Jian, Li Li, Zhang Jitan^*, Xie Meihua^* “Expeditious Synthesis of Phenanthridines through Pd/MnO₂-Mediated C-H Arylation/Oxidative Annulation Cascade from Aldehydes, Aryl Iodides and Amino Acid” Chem. Commun. 2020, 56, 2775-2778. DOI: 10.1039/d0cc00300j
    

11. Fan Jian, Zhao Yiming, Zhang Jitan, Xie Meihua* and Zhang Yuzhong* “Acid-Controlled Access to β-Sulfenyl Ketones and a,β-Disulfonyl Ketones by Pummerer Reaction of β-Keto Sulfones and Sulfoxides” J. Org. Chem. 2020, 85, 691-701. DOI: 10.1021/acs.joc.9b02766

12. Zhang Jitan*, Xu Qiaoqiao, Wu Jiaping, Fan Jian and Xie Meihua* “Construction of N-C Axial Chirality through Atroposelective C-H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis” Org. Lett. 2019, 21, 6361-6365. DOI: 10.1021/acs.orglett.9b02243

13. Zhang Jitan*, Wu Manyi, Fan Jian, Xu Qiaoqiao, Meihua Xie* “Selective C-H Acylation of Indoles at the C4 Position by Pd(II) Catalysis” Chem. Commun. 2019, 55, 8102-8105. DOI: 10.1039/c9cc03893k

14. Liu Changqing, Wang Bo, Guo Ziyi, Zhang Jitan, Xie Meihua* “Metal-Free Cascade Rearrangement/Radical Addition/Oxidative C-H Annulation of Propargyl Alcohols with Sodium Sulfinates: Access to 2-Sulfenylindenones” Org. Chem. Front. 2019, 6, 2796-2800. DOI: 10.1039/C9QO00688E

15. Chen Jiahui, Jia Jing, Guo Ziyi, Zhang Jitan*, Xie Meihua* “NH₄I-Promoted N-acylation of amines via the transamidation of DMF and DMA under metal-free conditions” Tetrahedron Lett. 2019, 60, 1426-1429. DOI: org/10.1016/j.tetlet.2019.04.040

16.  Fan Jian, Wang Shengke, Chen Jiahui, Wu Manyi, Zhang Jitan*, Xie Meihua* “Synthesis of 2-Acetyl Trisubstituted Furans via Copper-Mediated Deacylation Cleavage of Unstrained C(sp³)-C(sp²) Bonds” Org. Chem. Front. 2019, 6, 437-441. DOI: 10.1039/c8qo01139g

17. Zhang Jitan*, Liang Zhenda, Wang Jun, Guo Ziyi, Liu Changqing, Xie Meihua* “Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine and Sodium Sulfinates” ACS Omega 2018, 3, 18002-18015. DOI: 10.1021/acsomega.8b02966

18. Liu Changqing, Fan Jian, Wu Manyi, Chen Jiahui, Zhao Yiming, Xie Meihua* “Metal free mono- and 2,3-bis-sulfenylation of indoles in water with sodium sulfinates as a sulfur source” Chin. J. Chem. 2018, 36, 819-825. 

19. Xie Meihua*, Wang Shengke, Wang Jun, Fang Kuang, Liu Changqing, Zha Chao, Jia Jing “Construction of Substituted Benzenes via Pd-Catalyzed Cross-Coupling/Cyclization Reaction of Vinyl Halides and Terminal Alkynes” J. Org. Chem. 2016, 81, 3329-3334. DOI: 10.1021/acs.joc.6b00308

20. Wang Shengke, Liu Changqing, Jia Jing, Zha Chao, Xie Meihua*, Zhang Nianrong “Synthesis of sulfonyl-substituted furans via copper-mediated annulation of acetylenic sulfones and activated methylenes” Tetrahedron 2016, 72, 6684-6691. DOI: org/10.1016/j.tet.2016.08.081

21. Liu Changqing, Zha Chao, Jia Jing, Fan Jian, Liang Zhenda, Yin Zhengchun, Sun Ying, Xie Meihua* “Three-component coupling of acetylenic sulfones, Grignard reagents and α, β-unsaturated carbonyls: a convenient synthesis of diallylic alcohols”J. Organomet. Chem., 2016, 825-826, 75-82. DOI: org/10.1016/j.jorganchem.2016.10.026

22. Xie Meihua*, Wang Jun, Fang Kuang, Wang Shengke, Yan Liqin “Regio- and Stereoselective Synthesis of (E)-β-Halo Alkenyl Ketones/Sulfones via Haloallylation of Alkynyl Ketones/Sulfones” Tetrahedron Lett. 2015, 56, 4388-4391. DOI: 10.1016/j.tetlet.2015.05.098.

23. Liu Changqing, Zhang Zhannan, Zhang Jitan, Liu Xing, Xie Meihua* “Regioselective Synthesis of Aurone Derivatives via PBu₃-Catalyzed Cyclization of 2-Alkynoylphenols” Chin. J. Chem., 2014, 32, 1233-1237.

24. Xie Meihua*, Zhang Jitan, Ning Peng, Zhang Zhannan, Liu Xing, Wang Linbo “Regio- and stereoselective synthesis of highly functionalized vinyl ethers via coiodination of acetylenic ketones” Tetrahedron Lett. 2014, 55, 1065-1067.

25. Zuo Wansheng, Zhang long, Xie Meihua*, Deng Liang* “Square Planar Nickle(II) Complexes with Halogenated o-Diiminobenzosemiquinonato Ligation: Synthesis, Characterization, and Redox Property” Chin. J. Chem., 2013, 31, 1473-1482.

26. Fang Kuang, Xie Meihua*, Zhang Zhannan, Ning Peng, Shu Guanying “Nickel-catalyzed cross-coupling reaction of acetylenic sulfones with alkynyl Grignard reagents: a facile method for the preparation of unsymmetrical 1,3-diynes” Tetrahedron Lett. 2013, 54, 3819-3821. DOI: 10.1016/j.tetlet.2013.05.049

27. Xie Meihua*, Li Ming, Liu Changqing, Zhang Jitan, Feng Chengyou “Facile Regioselective Synthesis of 5-Hydroxy-4,5-dihydroisoxazoles from Acetylenic Ketones” J. Heterocyclic Chem. 2012, 49(6), 1462-1465. DOI 10.1002/jhet.1033

28. 张继坦，张金花，方旷，束官莹，谢美华* “Fe(III)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚”有机化学，2012, 32, 1533-1538. DOI 10.6023/cjoc1202271

29. Xie Meihua*, Feng Chengyou, Zhang Jitan, Liu Changqing, Fang Kuang, Shu Guanying, Zuo Wansheng “CuI-Catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones: convenient access to tetrasubstituted allylic alcohols” J. Organomet. Chem., 2011, 696, 3397-3401.

30. Xie Meihua*, Zhao Xinyang, Lin Gaofeng, Zhang Jinhua “FeCl₃·6H₂O-Catalyzed bromocyclization to access functionalized dihydropyrans” Synth. Commun. 2011, 41, 1227-1238.

31. Xie Meihua*, Xie Fadong, Lin Gaofeng, Zhang Jinhua “Convenient synthesis of bis(indolyl)alkanes and bis(pyrrolyl)alkanes by Cu(OTf)₂-catalyzed addition of indole and pyrrole to acetylenic sulfone” Tetrahedron Lett. 2010, 51, 1213-1215.

32. Xie Meihua*, Lin Gaofeng, Zhang Jinhua, Li Ming, Feng Chengyou “Regio- and stereoselective synthesis of tetrasubstituted allylic alcohols by three component reaction of acetylenic sulfone, dialkylzinc, and aldehyde” J. Organomet. Chem., 2010, 695(6), 882-886.

33. Xie Meihua*, Zhang Jinhua, Zhao Xinyang, Lin Gaofeng “An efficient synthesis of polysubstituted dihydropyrans via iodocyclization reaction of allylic alcohols” Chin. J. Chem., 2010, 28(6), 961-966.

34. Xie Meihua*, Wang Jialiang, Zhang Wei, Wang Shaowu* “Regio- and stereospecific synthesis of vinyl halides via carbozincation of acetylenic sulfones followed by halogenation” J. Organomet. Chem., 2009, 694, 2258-2262.

35. Xie Meihua*, Gu Xiaoxia, Wang Jialiang, Zhang Jinhua, Lin Gaofeng, Wang Shaowu “Regio- and stereospecific synthesis of polysubstituted alkenes by carbozincation of acetylenic sulfones” Appl. Organomet. Chem. 2009, 23, 258-266.

36. Xie Meihua*, Sun Ying, Zhang Wei, Gu Xiaoxia, Zhao Xinyang, Xie Fadong, Wang Shaowu “Stereoselective synthesis of allylic amines by one-pot tandem reaction of acetylenic sulfone, Grignard reagent, and N-tosylimine” Synth. Commun. 2008, 38(21), 3785-3796.

37. Gu Xiaoxia, Xie Meihua*, Zhao Xinyang, Sun Ying, Zhang Wei, Xie Fadong, Wang Shaowu “An efficient synthesis of polysubstituted 1,3-enynes from (E)-β-iodovinyl sulfones and terminal alkynes” Chin. J. Chem., 2008, 26, 1625-1629.

38. Xie Meihua*, Wang Jialiang, Gu Xiaoxia, Sun Ying, Wang Shaowu* “Highly regio- and stereoselective synthesis of tetrasubstituted olefins by the three-component tandem reaction of allyzinc bromide, acetylenic sulfone, and halohydrocarbon” Org. Lett. 2006, 8(3), 431-434.

39. Gao, Minli, Tang Yong*, Xie Meihua, Qian Changtao, Xie Zuowei* “Synthesis, structure, and olefin polymerization behavior of constrained-geometry group 4 metallacarboranes incorporating imido-Dicarbollyl ligands” Organometallics 2006, 25, 2578.

40. Xie Meihua*, Liu Li, Wang Jialiang, Wang Shaowu* “Stereoselective synthesis of vinyl sulfones by carbomagnesiation of acetylenic sulfone in the presence of CuCN” J. Organomet. Chem., 2005, 690, 4058-4062.

41. Xie Meihua, Huang Xian* “Highly Stereoselective Synthesis of Phenylseleno- and p-Tolylsulfonyl Substituted 1, 3-Dienes from Functionalized Allyl Alcohols” Chin. J. Chem., 2004, 2, 184.

42. Xie Meihua, Liu Xinyuan, Wang Shaowu*, Liu Li “Synthesis, Structure and Catalytic Activity Comparison of Tris- and Tetracoordinated Lanthanide Amides” Chin. J. Chem. 2004, 22, 678.

43. Xie Meihua,, Huang Xian* “Crystal Structures of (Z)-1-Phenyl-1-phenylseleno-2-(p- Tolylsulfonyl)ethene and (Z)-1,3-DiPhenyl-3-phenylseleno-2-(p-tolylsulfonyl) -2-propen-1-ol” Chin. J. Struct. Chem. 2004, 23, 543.

44. Xie Meihua, Huang Xian* “Carbomagnesiation of Acetylenic Sulfones Catalyzed by CuCN and its Application in the Stereoselective Synthesis of Polysubstitited Vinyl Sulfones” Synlett 2003, 4, 477-480.

45. Xie Meihua, Huang Xian* “Stereoselective Synthesis of Substituted Allyl Selenide by the Reaction of (E)-3-Selanyl Vinylzirconocene Chloride with Aldehydes or Acyl Chlorides” J. Chem. Research 2003, 4, 138.

46. Xie Meihua, Huang Xian* “Preparation of Selanyl-substituted Conjugated Enynes by Copper-catalyzed Coupling Reaction of (E)-g-Selanyl Vinylzirconocene with Acetylenic Bromide” J. Chem. Research 2003, 9, 584.

47. Xie Meihua, Wu Luling, Huang Xian* “A Stereoselective Synthesis of Substituted Allyl Alcohol By Three Component Reaction of Actylenic Sulfone, Phenylselenomagnesium Bromide and Ketones” Chinese Chem. Lett. 2003, 14, 887.

48. Xie Meihua, Wu Luling, Huang Xian* “Stereoselective Synthesis of d -Selanyl Allylic Alcohols by Hydrozirconation of Propargyl Selenides” Chinese Chem. Lett. 2003, 14, 255.

49. Huang Xian*, Xie Meihua “Michael-aldol Tandem reaction of acetylenic sulfone, Phenylselenomagnesium Bromide and Aldehyde. An Efficient Synthesis of Functionalized Allylic alcohols” Org. Lett. 2002, 4, 1331-1334.

50. Huang Xian*, Xie Meihua "Highly Stereoselective Three-component Reactions of Phenylselenomagnesium Bromide, Acetylenic Sulfones and Saturated Aldehydes/Ketones or α，β -Unsaturated Enals or Enones" .J. Org. Chem., 2002, 67, 8895-8900.

51. Xie Meihua, Hao, Xueshi, Ma, Huaizhu “Crystal Structure of Bis{1-(2-methoxyethyl) indenyl}dysprosium Chloride” Chinese J. Struct. Chem. 2000, 19, 253-258.

52. Xie Meihua, Qian, Changtao*, Gao, Lijuan, Sun, Jie “Synthesis and Structure of Barium Complex Containing 2,2,6,6-tetramethyl-3,5-heptanedionate and 1, 10-Phenanthroline Ligands” Chinese J. Struct. Chem. 2000，19, 419-422.

53. Ma Yun, Qian Changtao.*, Xie Meihua, Sun Jie “Lanthanide Chloride Catalyzed Imino Diels-Alder Reaction. One-Pot Synthesis of Pyrano[3,2-c]- and Furo[3,2-c]quinolines” J. Org. Chem. 1999, 64, 6462.

54. Shen Furen*, Xie Meihua, Hu Jiping, Wang Shaowu “Synthesis and Structural study of Cyclopentadienyl Lanthanide Derivatives Containing the 2-Naphthoyltrifluoroacetonato Ligand” Polyhedron 1996, 15, 1151.

55. Shen Furen*, Hu Jiping, Xie Meihua, Wang Shaowu “Synthesis and Structural investigation of Lanthanide Organometallics involving cyclopentadienyl and 2-naphthoyltrifluoroacetonato chelate ligands” J. Organomet. Chem. 1995, 484, C6-C9.

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